Target predictability influences the distribution of coordinated eye-head gaze saccades in patients with homonymous hemianopia

Abstract

In hemianopic patients target predictability plays a differential role for the distribution of different types of initial saccades. A linear correlation was shown to exist between the adaptive state of reading capability and the probability of a correct initial eye-head gaze saccade that hit the target accurately. A constant target frequency of 0.8 Hz was found to be the optimum frequency for hemianopic patients to follow square step targets with an eccentricity of ±20°. Variability of the compensatory eye movement velocity gain was lowest at this frequency. We were able to use this target frequency as a test for a clinical classification of the status of adaptation of hemianopic patients in combination with simple reading tests. The repetition of this manoeuvre could correct the synkinesis and the balance of the VOR during active gaze of hemianopic patients. [Neurol Res 1996; 18; 425-439]     

抗糖尿病药致不良反应的文献分析

目的：探讨抗糖尿病药致不良反应发生的情况,为临床合理用药服务。方法：通过中国期刊全文数据库（CNKI）收集1998-2011年发表的抗糖尿病药致不良反应发生的相关文献,对不良反应发生的患者性别与年龄构成、发生时间分布、累及器官或系统、药品种类等进行汇总、分析。同时对糖尿病并发症相关药物的不良反应亦做了归纳与分析。结果：抗糖尿病药引发不良反应的年龄主要集中于51岁以上;发生时间主要集中于1d～2个月;累及器官或系统涉及全身各大系统,其中最常见的为胃肠道反应;严重不良反应主要发生于心血管系统、免疫系统、内分泌系统中,包括室性早搏、低血糖性昏迷、过敏性休克、全身剥脱性皮炎甚至死亡等。结论：糖尿病及其并发症治疗药物产生的不良反应是广泛的,有些甚至是严重的;广大临床医师及药师应对其进行密切的监测,积极推进抗糖尿病药临床合理使用。     

文献检索课一体化教学与开放实习室教学研究

研究文献检索课一体化教学与开放学习室的教学模式对教学效果的影响，对采用不同授课方法两组学生的考试成绩和各项能力进行分析统计，结果表明新的教学模式能明显提高学生考试成绩和各种能力并有助于提高教师水平。     

婴儿组织胞浆菌病1例并文献复习

目的提高对婴儿组织胞浆菌病(histoplasmosis,HP)的认识。方法报告1例婴儿组织胞浆菌病,并结合文献对该病病原学、流行病学、临床表现、诊断和治疗等方面进行分析。结果婴儿HP以不规则发热、咳嗽、腹泻、肝脾肿大为主要临床表现,骨髓穿刺检查找到组织胞浆菌确诊。结论 HP是由荚膜组织胞浆菌感染所致的一种以侵犯网状内皮系统或肺部为主的深部真菌病。婴儿HP临床表现多样,以播散型为主,病情进展迅速,在短期内即可造成多器官功能衰竭而导致救治失败。确诊有赖病原学的检查。     

The Herniated Thoracic Disc: A Review of Literature

Abstract

This literature review discusses the epidemiology and etiology of thoracic disc lesions and describes signs and symptoms, diagnostic procedures, differential diagnosis, and treatment. Data presented in case series reports published between 1985-2001 is summarized: Thoracic disc herniations are more common than previously thought. They may cause mild, moderate, severe or confusing symptoms or be asymptomatic; 49% of cases were in men and 51% in women. Trauma was a precipitating factor in 31%; multiple herniations were reported in 9%. In symptomatic cases, 57% of patients presented with radicular pain, 48% with back pain, 63% with weakness, 60% with sensory complaints, 25% with bowel or bladder symptoms, and 59% with hyperreflexia. Typical presentations of upper, middle, and lower thoracic disc are summarized. Diagnosis is made by correlating clinical signs and symptoms with the results of diagnostic imaging. Surgery is recommended for patients with progressive neurological dysfunction. Research on the efficacy of conservative treatment is lacking in the literature.     

儿童叙事与阅读理解关系的研究进展

叙事是儿童语言能力发展的重要方面,对儿童学业学习,特别是阅读理解有着重要作用。本文梳理了以往研究儿童叙事与阅读理解的方法,总结了叙事与阅读理解之间的关系,并分析了通过叙事干预提升儿童阅读能力的研究。同时,为未来开展相关研究提出了方向。     

头孢唑肟致溶血性贫血文献分析

摘 要 目的：探讨头孢唑肟致溶血性贫血的临床特点及相关因素，为临床安全用药提供参考。方法：检索中国知网、万方、维普、PubMed数据库截止2017年1月31日公开发表的头孢唑肟致溶血性贫血的文献，对获得文献中患者的一般情况 、临床表现、溶血发生时间、转归及发生机制等相关因素进行统计分析。结果：共检索到相关文献17篇，病例21例；其中男16例（76.19%），年龄分布以60岁以上年龄段最多（9例，42.86%）；溶血反应多发生在用药后的7 d内（18例，85.71%）；贫血纠正的平均时间为7.5 d，血红蛋白值与贫血恢复时间呈负相关。3例（14.29%）患者救治无效死亡。发生机制主要为免疫复合物和药物吸附。结论：临床医师和药师应了解头孢唑肟导致溶血性贫血的发生规律，正确选择用药人群，加强用药监护及用药教育，尽早识别严重不良反应并及时处理。     

Stroop interference associated with efficient reading fluency and prelexical orthographic processing

The Stroop Color–Word Test involves a dynamic interplay between reading and executive functioning that elicits intuitions of word reading automaticity. One such intuition is that strong reading skills (i.e., more automatized word reading) play a disruptive role within the test, contributing to Stroop interference. However, evidence has accumulated that challenges this intuition. The present study examined associations among Stroop interference, reading skills (i.e., isolated word identification, grapheme-to-phoneme mapping, phonemic awareness, reading fluency) measured on standardized tests, and orthographic skills measured on experimental computerized tasks. Among university students (N = 152), correlational analyses showed greater Stroop interference to be associated with (a) relatively low scores on all standardized reading tests, and (b) longer response latencies on orthographic tasks. Hierarchical regression demonstrated that reading fluency and prelexical orthographic processing predicted unique and significant variance in Stroop interference beyond baseline rapid naming. Results suggest that strong reading skills, including orthographic processing, play a supportive role in resolving Stroop interference.     

天水医事简略

天水地处甘肃东南部,历史悠久,医疗卫生源远流长,名家辈出,由于古时兵乱灾疫较多,加之造纸术,印刷术落后,使得众多珍贵文献难以保存至今,本文就笔者研习所得做一简要阐述。     

核仁磷酸蛋白(NPM/B23)与子宫内膜癌关系的研究进展

核仁磷酸蛋白(NPM/B23)是一类穿梭于核仁、核质和胞质的多功能蛋白质。核仁磷酸蛋白参与核糖体的生物合成,控制中心体复制,并可通过多种信号通路调节细胞增殖和凋亡,参与肿瘤的发生。近年来对NPM/B23的研究多集中于NPM/B23基因突变与血液肿瘤的关系,另有许多研究表明NPM/B23在一些实体肿瘤中过表达,并与肿瘤的发生、发展密切相关。核仁磷酸蛋白可能是许多实体肿瘤的肿瘤标志物之一,但其在子宫内膜癌中作用的报道较少。因此,该文就核仁磷酸蛋白及其与子宫内膜癌关系的研究现状进行综述。